Combinatorial Modulation of Protein Prenylation
نویسندگان
چکیده
منابع مشابه
Biochemistry of protein prenylation.
Covalent modification by isoprenoid lipids (prenylation) is now recognized as a mechanism to promote membrane interactions and biological activities of a variety of cellular proteins. Both the 15-carbon farnesyl and 20-carbon geranylgeranyl isoprenoids are involved in these modifications, which occur on carboxyl-terminal cysteine residues of proteins (Fig. 1). Known prenylated proteins include ...
متن کاملProtein prenylation in spinach chloroplasts.
Protein prenylation in plants was studied by in vivo metabolic (3)H-mevalonate labeling in combination with a range of protein synthesis inhibitors. In spinach cotyledons, this posttranslational protein modification was found to be divided into two categories, one representing the conventional prenylation involving farnesyl and geranylgeranyl groups bound to cysteine residues via thioether link...
متن کاملMechanisms of protein prenylation and role in G protein function.
Introduction Covalent attachment of isoprenoid lipids is now recognized as an important modification of many proteins involved in cellular signalling [ 1,2]. This type of modification, termed prenylation, involves attachment of either the 15-carbon farnesyl or 20carbon geranylgeranyl isoprenoid to C-terminal cysteine residues of proteins. Known prenylated proteins include a number of GTP-bindin...
متن کاملProtein prenylation: a pivotal posttranslational process.
The joining of the 15-carbon farnesyl group ðC15H25Þ and the 20-carbon geranylgeranyl group ðC20H33Þ to protein–cysteines at or near their carboxy-termini is catalyzed by protein farnesyltransferase (FTase) and protein geranylgeranyltransferase-I and II (GGTase-I and GGTase-II) [1]. The prenyltransferases are heterodimers consisting of aand b-subunits with combined molecular masses ranging from...
متن کاملProtein prenylation: genes, enzymes, targets, and functions.
PROTEINS INVOLVED IN PRENYL-DEPENDENT PROCESSING .......... 217 Protein Prenyltransferases ................................... 218 Proteases ............................................. 221 Reversible Modifications .................................... 223 PRENYL-MEDIATED INTERACTIONS ........................... 225 Prenyl-protein Receptors .................................... 225 Lipid Interac...
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ژورنال
عنوان ژورنال: ACS Chemical Biology
سال: 2007
ISSN: 1554-8929,1554-8937
DOI: 10.1021/cb700062b